Methadone hydrochloride

Methadone hydrochloride (referred to methadone) for the μ opioid receptor agonist, a similar efficacy to morphine, has analgesic effects and can cause respiratory depression, miosis, sedation and so on. Compared with morphine, with a role in a long time, not easy to produce tolerance, drug dependence and low, is synthesized in Germany during World War II instead of the narcotic analgesics morphine. 60 in the early 20th century, found the drug in treating heroin dependence and the role of alternative maintenance treatment efficacy.
Good oral absorption of methadone, 30 minutes after the onset of medication, 4 hours peak plasma concentration, the duration of action 24 to 36 hours, t1 / 2 was 15 to 18 hours, plasma protein binding rate of 85% to 90%; mainly in liver and excreted by the kidneys and bile, repeated administration of the role of organized accumulation.
Adaptation like:
1. For trauma, surgery, cancer, severe pain caused by the analgesic treatment.
2. Detoxification for opioid dependence treatment.
3. Alternative for opioid maintenance therapy.


Used with caution and Taboo:
Respiratory dysfunction, infants and young children, parturients (delivery) disabled; pregnant women, the elderly, liver and kidney dysfunction caution.