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Oral PDE-5 Inhibitors For Recurrent Priapism
Priapism is a devastating condition in men that can lead to long lasting deleterious effects on erectile function (ED). In sickle cell patients it may be recurrent, often initiated by a normal nocturnal erection. These recurrent episodes are described in the older literature as 'stuttering'; the erections are evident up awakening and fail to subside after morning voids. There are two types of priapism: ischemic or non-ischemic (high flow). Occurrences of ischemic priapism are usually idiopathic or drug-related. Men with sickle cell trait or disease can particularly be afflicted. Non-ischemic priapism is usually associated with trauma. Priapism can appear as an isolated episode or recurrent with attacks as frequent as everyday. In order to prevent or treat this condition, scientists are studying if dysregulated phosphodiesterase-5 (PDE-5) may have the efficacy. Finally, they concluded that the treatment with the PDE-5 inhibitors resets the dysregulation, thereby restoring normal function and protects against future recurrence. |
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